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Mechanism of destruction of the disulfide S-S bond in palladium compounds with sulfur-containing biomolecules has been described.
Jan 29, 2019 | 14:11 / Interesting information
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The chemists from the Siberian Federal University (SFU), together with colleagues, have described the disruptive S-S bond disproportionation mechanism in 3,3'-dithiodipropionic acid and dl-homocystine triggered by palladium (II) ions.

In case of disproportionation, one and the same element gives and receives electrons, and in products it changes the degree of oxidation. The results of the study, supported by the RFBR grant, have been published in the journal Polyhedron.

Complex compounds of noble metals, such as palladium and platinum, with sulfur-containing biomolecules play a significant role in the metabolism of anticancer drugs.

In this paper, we studied the process by using spectrophotometry, and controlled it by changing the concentration of final products, ”says the main author of the study, Alexander Petrov, an employee of the Siberian Federal University, the Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences and the Institute of Chemistry and Chemical Technology of the Siberian Branch of the RAS .

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